Anisole

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Anisole (Methoxybenzene) is an organic compound with a pleasant, sweet aroma and is widely used in pharmaceuticals, perfumes, and chemical synthesis. It is a colorless liquid that serves as an important intermediate in the production of fragrances, agrochemicals, and dyes.Anisole, or methoxybenzene, is an organic compound with the formula CH3OC6H5. It is a colorless liquid with a smell reminiscent of anise seed, and in fact many of its derivatives are found in natural and artificial fragrances. The compound is mainly made synthetically and is a precursor to other synthetic compounds. Structurally, it is an ether (−O−) with a methyl (−CH3) and phenyl (−C6H5) group attached. Anisole is a standard reagent of both practical and pedagogical value.




Chemical Properties



  • Chemical Formula: C₇H₈O

  • Molecular Weight: 108.14 g/mol

  • Boiling Point: ~154°C (309°F)

  • Density: ~0.995 g/cm³

  • Solubility: Slightly soluble in water, highly soluble in organic solvents

  • Aroma: Sweet, floral scent


Common Applications



  • Fragrance & Perfume Industry – Used in the production of floral and sweet-smelling scents.

  • Pharmaceuticals – Acts as an intermediate in drug synthesis.

  • Agrochemicals – Used in the manufacture of pesticides and herbicides.

  • Dye & Polymer Industry – Precursor for organic dyes and resins.

  • Flavor & Food Additives – Occasionally used as a flavoring agent.


Electron Beam Lithography on Nonplanar Surfaces:  Research highlighted the application of anisole in electron beam lithography for structuring on nonplanar and irregular surfaces, providing significant advancements in microfabrication technologies crucial for developing miniaturized devices and components (Zhu et al., 2024).

Photonic Pigments Synthesis: The research by Xu et al. (2024) illustrates how anisole is instrumental in the sustainable synthesis of photonic pigments via polystyrene-block-polyvinylpyrrolidone bottlebrush block copolymers. This application underscores anisole’s significant role in advancing material science, particularly in the development of innovative materials tailored for optical applications.

Development of SERS Platforms: Explores the use of anisole in the fabrication of highly flexible copper tape decorated with Ag nanoarrays for ultrasensitive surface-enhanced Raman spectroscopy (SERS) platforms, highlighting its utility in enhancing the detection capabilities for environmental and chemical sensing (Shameer et al., 2024).

Health & Safety Considerations




  • Flammable Liquid: Keep away from heat, sparks, and open flames. Therefore, ensure storage in a cool, well-ventilated area.

  • Irritant: Can cause skin and eye irritation upon direct contact. Thus, using protective equipment like gloves and safety glasses is advisable.

  • Inhalation Risk: Vapors may cause dizziness, nausea, or respiratory discomfort. Consequently, it’s important to work in a well-ventilated space or use respiratory protection.

  • Environmental Impact: Should not be released into water sources; hence, proper disposal is essential. Moreover, consider the impact on local ecosystems when handling or disposing of this chemical.



Handling & Storage Recommendations


  • Use Protective Gear: Wear gloves, goggles, and protective clothing. Thus, you protect yourself from direct contact and potential chemical hazards.

  • Ensure Proper Ventilation: Work in a well-ventilated area or fume hood. Therefore, you minimize inhalation risks and maintain a safer working environment.

  • Store Safely: Keep in tightly sealed containers away from ignition sources. Hence, you prevent accidental fires or chemical reactions.

  • Dispose Responsibly: Follow local environmental regulations for disposal. Consequently, this ensures that you contribute to environmental safety and comply with legal standards.



Analysis Note
Assay (GC, area%): ≥ 99 %
Density (d 20 °C/ 4 °C): 0.993 – 0.994
Identity (IR): passes test



Conclusion


Anisole is a versatile compound with applications in fragrances, pharmaceuticals, and industrial chemicals. While it offers significant benefits in various industries, it is essential to handle it with care due to its flammability and potential health hazards.


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